Human Papilloma Virus and Cancers

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Human Papilloma Virus and Cancers

HUMAN PAPILLOMA VIRUS AND CANCERS
By Sameera Mohotti (BSc, MSc, MD(MA))

In recent years, it has become clear that certain types of human cancers have a viral component to their etiology. Cancers due to Human Papilloma Virus (HPV) are most common among these. This has been a study of intense research for number of years. Specific types of HPV genotypes were found to be the causative agents of some common cancers, most notable invasive cervical carcinoma. Apart from this anogenital cancer, HPV’s are also causally associated with other anogenital cancers such as cancers of vulva, vagina, penis and anus. HPV is also responsible for approximately 20-30% of head and neck cancers [1].

Association OF HPV with Cervical cancer

The link between HPV and cervical cancer is now established beyond doubts. Many epidemiological [2], [3] and molecular evidences [4] suggest the causal association of HPV’s with cervical cancer. It has been estimated that about 500,000 women acquire cervical cancers every year and 75% of this are from developing countries. In United States about 13000 cervical cancer cases are diagnosed every year and about 7000 deaths annually from prevalent disease [5].
Evidence suggests that the great majority of all grades of cervical intraepithelial neoplasia can be attributed to cancer-associated types of HPV infections [3]. It has been estimated that only about 10% of the HPV patients would develop cervical dysplasia and of these only few people would develop cervical cancer. Studies conducted on HPV DNA in a variety of genital lesions suggested that HPV types 16 and 18 are most closely associated with risk of genital cancers [4] and some of HPV types are considered to be more prevalent among cervical cancer patients in a specific geographical areas; HPV 45 in Western African [6].
The development of cervical cancer is associated with factors other than just high risk HPV infection. Factors like impaired cell mediated immunity, long term use of contraceptives and smoking also increase the risk of gaining and the persistence of HPV types which in turn may lead to cervical cancers [7],[8].

Association of HPV with other anogenital cancers

Strong links between HPV and anogenital cancers such as penile, anal, vulvar cancers have been demonstrated by many studies. These cancers are formed from lesions develop in the vagina, vulva, penis and anus as the result of sexual contact [9]. But the exact role of HPV in the natural history of anal squamous intraepithelial lesions is still unknown [10].
Studies indicate that about 1% of sexually active adults in the United States show visible genital wart and about 15 % have sub clinical infection. The most commonly detected HPV types were found to be HPV 16 and 18 [11]. But, HPV types 56, 59-64 and 71 also have been isolated in vulvar intraepithelial neoplasia [12] .

Association of HPV with head and neck cancer

The term head and neck cancer refer to the cancers in the oral cavity, lip, nose, para nasal sinuses, naso-pharynx, oro-parynx, larynx, oesophagus, salivary glands, soft tissues of the neck and ear. Oral cancer is the sixth most prevalent cancer worldwide and about 620,000 patients are diagnosed with cancer of oral cavity every year [13]. Many studies have found evidence suggestive of a role for human papilloma virus in head and neck cancer [14],[15]. Though the exact mode of transmission of HPV infection in the head and neck region has not been determined, it’s association with sexual behavior and perinatal transmission have been demonstrated [16].
During the pathogenesis of HPV, it enters to the host through the mucosal epithelial layer surface. Oral mucosa resembles the mucosa of the genital region in their histological structure. As the correlation between HPV and cervical cancer are well established, the resemblance of the mucosal histology led to the suggestion that HPV could play a role in the development of benign and malignant lesions of the oral mucosa [17].
After the first report of papilloma virus in tongue carcinoma[14], many studies have shown the presence of HPV DNA in oral cavity [15] and head and neck cancer [13]. The most prevalent HPV types in these were found to be HPV 16 and 18. Further epidemiologic and molecular investigation should be carried out to establish a precise relationship between HPV and head and neck cancer.

HPV INDUCED CANCER DETECTION

Detective measures to date have centered on screening programs for HPV induced cancers. The most common and the traditional way of screening for cervical cancer and cervical dysplasia are to conduct a pap smear test. This has significantly reduced the incidence of cervical cancers in recent years. If the result is turned out to be positive, then the colposcopy would be carried. Since cervical cancer and anal cancer resembles in their biological features, it has been observed that screening for anal high grade squamous intraepithelial lesions with anal pap smear allows detecting individuals at risk of developing anal cancers. To obtain a confirmatory result, an anoscopic examination should be performed [18, 19].
Detection of earlier stage of head and neck cancers as well as premalignant lesions can be done by regular physical examinations by the doctor. Any abnormalities should be further evaluated. An endoscopy is performed on the samples obtained from throat, larynx, and upper esophagus. Computed tomographic (CT) scans, magnetic resonances imaging (MRI) scans or ultrasounds could be performed to identify the size and extent to which the cancer has spread from its site of origin [20].
No standard screening tests are followed for vulvar cancers. In vulvar cancer lymph node pathologic status is the most important predictive factor. A study conducted by De Ceccoc et al indicated that Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance are easy and reliable methods for the detection of sentinel node in early vulvar cancer [21]. Coloscopy can also be used to detect abnormalities on vulvar epethilia [19].
The above mentioned tests cannot be used to detect the presence or absence of the virus which would eventually cause a cancer. A test based on the hybrid capture technologies is now available to detect 13 cancer causing kinds of HPV. This technology is based on the principle of signal amplification of a hybrid species produced by RNA probes fixed with HPV DNA [22]. Polymerase chain reaction is one of the most sensitive tests for HPV DNA detection [23]. But Zhao M. et al suggest that there could be limitations in this method when applying to a broad population [24]. Studies indicate that HPV DNA testing is one of the most effective tests which could be used for the prevention of cervical cancer [25].
In a study conducted by Reid et al, to compare the efficacy of cervical cytology, cervicography and/or DNA hybridization for cervical cancer screening, showed that none of the tests succeeded in identifying all the abnormalities [26].

REFERENCES

1. I. Benjamin Paz, N.C., Tamara Odom-Maryon, Yuan Xie, Sharon P. Wilczynski,, Human papillomavirus (HPV) in head and neck cancer. Cancer, 1997. 79(3): p. 595-604.
2. Koutsky, L.A., et al., A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med, 1992. 327(18): p. 1272-8.
3. Schiffman, M.H., et al., Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst, 1993. 85(12): p. 958-64.
4. JC Macnab, S.W., JW Cordiner, and JB Clements, Human papillomavirus in clinically and histologically normal tissue of patients with genital cancer. The New England Journal of Medicine, 1986. 315(17): p. 1052-1058.
5. Parkin, D.M., P. Pisani, and J. Ferlay, Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer, 1999. 80(6): p. 827-41.
6. Bosch, F.X., et al., Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst, 1995. 87(11): p. 796-802.
7. Calore, E.E., S.M. Pereira, and M.J. Cavaliere, Progression of cervical lesions in HIV-seropositive women: a cytological study. Diagn Cytopathol, 2001. 24(2): p. 117-9.
8. Brisson, J., et al., Risk factors for cervical intraepithelial neoplasia: differences between low- and high-grade lesions. Am J Epidemiol, 1994. 140(8): p. 700-10.
9. Jung, W.W., et al., Strategies against human papillomavirus infection and cervical cancer. J Microbiol, 2004. 42(4): p. 255-66.
10. Palefsky, J.M., et al., Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer. Cancer Res, 1991. 51(3): p. 1014-9.
11. Koutsky, P., Laura, Epidemiology of Genital Human Papillomavirus Infection. The American Journal of Medicine, 1997. 102(5, Supplement 1): p. 3-8.
12. Longuet, M., S. Beaudenon, and G. Orth, Two novel genital human papillomavirus (HPV) types, HPV68 and HPV70, related to the potentially oncogenic HPV39. J. Clin. Microbiol., 1996. 34(3): p. 738-744.
13. Syrjanen, S., Human papillomavirus (HPV) in head and neck cancer. J Clin Virol, 2005. 32 Suppl 1: p. S59-66.
14. de Villiers, E.M., et al., Papillomavirus DNA in human tongue carcinomas. Int J Cancer, 1985. 36(5): p. 575-8.
15. Palefsky, J.M., et al., Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. J Oral Pathol Med, 1995. 24(5): p. 193-7.
16. Szentirmay, Z., et al., Human papillomavirus in head and neck cancer: molecular biology and clinicopathological correlations. Cancer Metastasis Rev, 2005. 24(1): p. 19-34.
17. Woods, K.V., et al., Analysis of human papillomavirus DNA in oral squamous cell carcinomas. J Oral Pathol Med, 1993. 22(3): p. 101-8.
18. Sheary B, D.L., Cervical screening and human papillomavirus. Aust Fam Physician., 2005. 34(7): p. 578-80.
19. JD., O., Genitoanal papillomavirus infection–a diagnostic and therapeutic dilemma. Semin Dermatol., 1990. 9(2): p. 141-7.
20. Antunes, J.L.F., et al., Trends and spatial distribution of oral cancer mortality in Sao Paulo, Brazil, 1980-1998. Oral Oncology, 2001. 37(4): p. 345-350.
21. C De Cicco, M.S., M Bartolomei, C Grana, M Cremonesi, M Fiorenza, A Maggioni, L Bocciolone, C Mangioni, N Colombo and G Paganelli, Sentinel node biopsy in early vulvar cancer. British Journal of Cancer, 2000. 82: p. 295-299.
22. Thomas, R.J., Early Detection of Cervical Cancer -New diagnostics identify HPV. Modern Drug Discovery, 2000. 4: p. 57-58.
23. Miller CS, Z.M., White DK., Detection of HPV DNA in oral carcinoma using polymerase chain reaction together with in situ hybridization. Oral Surg Oral Med Oral Pathol., 1994. 77(5): p. 480-6.
24. Ming Zhao, E.R., Andre Lopes Carvalho, Wayne Koch, WeiWen Jiang, David Sidransky, Joseph Califano,, Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. International Journal of Cancer, 2005. 117(4): p. 605-610.
25. Denny, L.A., Human papillomavirus testing and screening. Best Practice & Research Clinical Obstetrics & Gynaecology, 2005. 19(4): p. 501-15.
26. Harry, T.C.S., K.M., Evaluation of the Hybrid Capture human papillomavirus deoxyribonucleic acid detection test. American Journal of Obstetrics & Gynecology, 1996. 175(3): p. 758-9.

Sameera Mohotti (BSc, MSc, Dip in Accu)


Article from articlesbase.com

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Question by Stephen W.: What causes cancer and what causes it to spread?
I don’t see how cancer can just grow and grow without the body being aware of it, technically speaking the human body should have evolved to compensate if we have had it for thousands of years which leads me to a logical conclusion; it is a fairly recent health problem with humans.

How does it spread too? It makes no sense for it to just ‘spread’, it isnt a virus or anything.

Half of these terms I do not understand, are these terms loose terms for the public and is there a more detailed explanation as to how cancer works?

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Answer by Emily
We don’t know what causes most cancers, although most all cancers have risk factors that increase your chances for getting it. I have no idea why we haven’t been able to compensate for it but I can only guess it’s because it has such an aggressive and powerful effect on the body and can thrive virtually anywhere in the body. Also, it’s not a recently acquired health problem. We just didn’t always have the knowledge of what cancer is and we certainly didn’t have the imaging studies used today in the diagnosis of most cancers. Anyways, cancer spreads because that’s basically all it knows how to do. Cancer starts out with a cell that doesn’t know how to stop dividing and as a result, multiplies out of control exact copies of itself that then go and multiply out of control too. Hope this answered some of your questions:)

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My family has a history of cancer, but no history of.hereditary cancer.
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None of these cancers were hereditary and no members of my immediate or extended family have ever been considered at increased risk of developing them.

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The Cancer Diet – 8 Things You Must Eat to Keep Cancer Away

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Mushrooms
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The cancer diet involves carefully selecting foods which have demonstrated health-giving properties and offer some protection against various forms of cancer. Numerous studies have shown the beneficial effects of specific foods in helping to prevent cancer or restore good health. Here are some that you should know about.

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The Cancer Diet – 8 Things You Must Eat to Keep Cancer Away

By Shelley Penney

Cancer statistics are exploding. Some studies say that 1 out of every 2 people will develop some form of cancer in their lifetime. The reality is staggering. Not only is the monetary cost of cancer a huge burden on individuals and society, but the emotional toll is huge as well.

The cure for this disease which plagues and terrifies us is an easy one. Get the proper nutrients into your body every day. Think about this for a moment and really take it in. Your body regenerates almost all of it’s cells on a cycle of every 7-10 years. It will use whatever building materials it has at hand to make those cells. It is my belief that cells made of artificial colors, junk foods void of nutrition, additives and chemicals, these cells will be the starting cells of tomorrows cancers.

The sooner you start eating better, the better your chances of never developing cancer at all. If you already have cancer, then you will need more help in the way of supplements along with changing your dietary habits. The more damage the cancer has done, the less likelihood there is of a complete reversal.

Keeping those points in mind, here are the foods to eat to stop this terrible in it’s tracks.

  1. Broccoli- Cruciferous vegetables like broccoli and cabbage have sulforaphane, a component which has been proven by science to stop cancer growth.
  2. Tomatoes- Lycopene is just one of the compenents of this healthy fruit that has been studied extensively for it’s disease fighting properties. People who eat tomatoes at least 2 times a week have 33% less chance of developing this plague. (Tomatoes and broccoli eaten together have an effect greater than if one is eaten separately from the other)
  3. Mushrooms- Mushrooms contain beta glucans. Medicinal mushrooms like red reishi, maitake, shiitake, cordyceps, and agaricus blazei have been extensively studied. These mushrooms have been shown in hundreds of thousands of scientific research studies to prevent or cure cancer. In fact there is even a patented extract of mushrooms that is prescribed by doctors in Asia to complement traditional chemotherapy.
  4. Green Tea- Another gift from our friends in Asia, green tea is loaded with catechins and polyphenols… big words that mean big anti-cancer benefits for you.
  5. Berries- the powerful anthocyanins in berries will help to turn off the growth of cancer.
  6. Salmon- and other fatty fish, as well as olive oil, avocado… these are all rich sources of omega 3 fatty acids. Omega 3 fatty acids are absolutely necessary for cell reproduction and healing, and are sorely lacking in our diets. Make sure you get wild pacific or alaskan salmon, as most atlantic salmon is now farmed which means it is also filled with antibiotics and has less omega 3 fatty acids than their wild counterparts.
  7. Garlic- has been proven to reduce the occurance of stomach, breast and esophagus tumors.
  8. Camu Camu- Many people still haven’t heard about Camu Camu or Acerola but I mention them because they are a super concentrated natural form of vitamin C. You absolutely MUST have vitamin C, and lots of it, if you hope to fight cancer and stay healthy. Vitamin C is absolutely essential in the healing process, and a nutrient that is often overlooked. Most people would benefit from large amounts of vitamin C supplementation if these high C fruits (or powders) aren’t available in grocery or health food stores.

I hope that you are getting the picture that an anti-cancer diet is one that is made up of real foods. You won’t see cheez stiks or french fries or a bacon double cheese burger on any list of cancer fighters. You must give your body building block and healing nutrients every single day and these are delivered to us naturally from the earth.

Eat well and fight off cancer.

Shelley Penney is a retired registered nurse with a continued, insatiable thirst for health and wellness information. Although Shelley hails from traditional medical training, she is always searching for ways in which the natural world of healing herbs, foods and supplements can intersect with traditional medicine and benefit us all. Visit Shelley on the web www.ShelleyPenney.com

Important Colon Cancer Prevention Methods

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Stomach colon rectum diagram.
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Many people are looking for information about Colon Cancer Prevention Methods, so have a look at this. s I am often searching for graphics, videos and other beneficial information which aids people to have more details about preventing cancer. Be sure to look over it all. Don’t forget to include your thoughts so the rest of us can be aware of your opinions:

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Colon Cancer Prevention Methods

Most people develop colon cancer rather slowly, over one or two years. The 1st stage of development happens when a mass of tissues, growths or polyps ( a cluster of benign growths ) grow in the colon walls. Polyp type cancers can grow into the wall of the gut, occupy nearby lymph nodes and spread to other organs in the body.

This is named “metastatic colon cancer” due to its mobility. In a few cases, the lining of the bowel might be irregular and inflamed, that may also lead to cancer.

To stop colon cancer, regular testing is important after the age of 50. Before talking about colon cancer prevention, let’s rap a little about what colon cancer is, precisely. Both the bowel and anus are a part of the gut. The 1st part of the gut, which is the esophagus and stomach, breaks down food to be processed into energy.

Next, the broken down food travels to the small intestines / bowel, which is a narrow, 20-foot section that continues breaking down food and soaking up almost all of the nutriments. The small intestine then sends the leftover material to the five-foot-long colon ( which is also known as “the huge intestine” ), where it absorbs salt and water and stores waste.

The 1st part of the bowel is the rising colon, which is attached to the small intestines and the appendix on the right side of the stomach. The cross colon runs from a right to the left side of the higher stomach. The descending colon travels downward on the left side and the sigmoid colon is an S-shaped portion that passes food matter down to the lower colon, the final 6 inches of the guts, that may pass food out of the body through the anal sphincter.

Nobody is truly sure what precisely causes a colon cancer cell to develop in the 1st place, or why some experience a colon cancer recurrence, but research commends a selection of life-style, hereditary and environmental components are at play. It could be not possible to fully forestall cancer of the bowel, but the North American Cancer Society announces that catching colon cancer symptoms early through screening tests is the key. Regular colon cancer screening should begin at age fifty for the majority, unless they are in a serious risk class.

Every year, people should get a fecal occult blood test, which is done by sending a stool sample. A stool DNA test might also be done at that very same time, since it also uses a stool sample to collect results. Then, each 5 years, patients should get a flexible sigmoidoscopy, which involves a long, flexible tube that checks the last few feet of the gut for colon polyps, and a double-contrast barium enema that uses an xray and dye to test the higher portion of the bowel.

A virtual colonoscopy employing a CT scan machine also should be done each five years. A colonoscopy process involves the insertion of a long, flexible tube, light and camera to view the whole colon and should then be done each ten years, or each 5 years if any irregularities have been found during the other screenings. Ultimately , life changes are a crucial way to stop colon cancer. It doesn’t need to be said that smoking, indolence and exorbitant alcohol consumption are contributors to many varieties of adversary health conditions.

Cancer of the colon prevention involves eating the proper foods, including cabbage, Brussels sprouts, carrots, beets, onions, potatoes, broccoli, artichokes, celery, beans, peas, multi grain products, berries, cantaloupes, mangoes, persimmons and dried apricots, for example. Limit the quantity of red beef ( meat, pork, lamb ) and processed meats ( hot dogs, luncheon meats ), cooking meats at extremely high temperatures ( frying, sauting and barbecuing ) and saturated fats.

Learn more about Colon Cancer Early Symptoms. Stop by Author Willie DeJarnette’s site where you can find out all about Colon Cancer Early Symptoms and what it can do for you.

Cancer – How to Deal With Stress

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A - normal cell division, B - cancer cell divi...
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If you’re interested in Stress and Cancer, you’ll welcome this. I am often looking for articles, videos and other beneficial information which assists readers to have more awareness of the implications of Cancer. Be sure to have a good look at it all. Don’t forget to offer your comments so the rest of us can enjoy your opinions:

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How to Deal With Stress When You Have Cancer

It is the diagnosis that nobody wants to hear. Despite all the advancements the field of medical science has made especially in the treatment and cure of cancer, cancer as a diagnosis is dreaded by all people alike. Cancers are of many kinds and they affect many parts of the body. Some cancers are found predominantly in women while others like prostate cancer are exclusively found in men.

Cancer can be extremely stress inducing. Stress is a state of physical or mental unrest. Stress is the condition when you find things not going your way and worrying and anxiously pondering over the situation again and again adds to the tension. Any illness can lead to stress and also stress can lead to many other illnesses like diabetes, high blood pressure, heart disease, depression and even cancer.

Cancer has become very much treatable today and there are many individuals who have survived the once fatal disease. Having cancer can cause people to become depressed due to the thoughts of death and mortality which become very active in their subconscious. Depression if not checked can lead to further stress. Another stressful thought caused by cancer is the thought of the mounting medical bills.

Chemotherapy and radiation sessions are not inexpensive. Add this to the hospital, medication and doctor’s costs and you have a huge medical bill in front of you. Your medical insurance many not cover all of these expenses and it could all lead to a drain on your finances. Worrying about depleting finances can lead to stress and other negative conditions.

It is important to keep a check on stress because untreated stress can lead to many other health complications. There are ways to tackle the stress which an illness brings on. It is important to stay in a positive frame of mind and in a cheerful demeanor. It is definitely not easy when one is undergoing treatment for a possibly fatal disease but at least that effort should be made. The treatment of cancer or any other life threatening condition becomes faster and quicker when a positive attitude is maintained.

In order to stay in a positive mind frame one can join a cancer group where patients with cancer or cancer survivors meet and speak about their battles or victories. These real life stories can be inspiring and can give one the determination and courage to go through the treatment. Another way to beat the stress is to read awe inspiring books about people who have beat the odds and come out victorious.

Taking the effort to make those little lifestyle changes while undergoing treatment for cancer can make the recovery faster and smoother. You can change your diet and increase the intake of fresh fruits, leafy green vegetables, and mineral and protein rich foods and anti oxidants rich foods like green tea for instance. The body becomes strongest and gains immunity which in turn is good for the treatment of cancer.

No matter what kind of cancer one has acquired, treatment and cure are not impossible if every sincere effort is taken along with constant prayers to God.

Orlando Vaccine Clinic. Dr. James S. Pendergraft opened the Orlando Women’s Center in March 1996. Pain Free Abortion, physical examinations, family planning and counseling. Abortion Clinic.Article Source:http://www.articlesbase.com/cancer-articles/how-to-deal-with-stress-when-you-have-cancer-1783486.html

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